Best Doctor for COVID-19 Infection Treatment in Mumbai Outpatient management is appropriate for most patients with COVID-19. The individual patient’s clinical and social circumstances as well as the available resources should be taken into account, when considering treatment options. The treatment should always been under supervision of a specialist. At present there has been recent spike in COVID-19 cases in India. Adults who are at increased risk for severe disease due to comorbidities and or vaccination status, early treatment with nirmatrelvir - ritonavir is recommended. The COVID -19 specific therapy should not be routinely used for immunocompetent adults aged less than 64 years of age who are up to date with recommended COVID-19 vaccinations and who have no other risk factors for progression to severe disease. Nirmatrelvir – ritonavir should be administered as soon as possible and within five days after symptom onset. For patients with normal renal function, the dose is nirmatrelvir 300 – ritonavir 100 mg orally twice daily for five days. If this drug is unavailable, remdesivir can be used. The evidence for molnupiravir is conflicting. Studies do not demonstrate efficacy against hospitalization or death. It is contraindicated for use in patients younger than 18 years due to bone and cartilage toxicity. It is also not recommended during pregnancy and lactation For patients with documented COVID-19, treatment with antibiotics including azithromycin, is not indicated. Bacterial superinfection is not a prominent feature of COVID -19. Similarly routine initiation of anticoagulant or antiplatelet therapy should be avoided. For mild infections six days of isolation from the onset of disease should be advised and similarly in those with moderate to severe symptoms, ten to twenty days of isolation is advisable. During the period of isolation, there should be regular update with the specialist.